dr ben lynch glutathione “MTHFR”, Gene Mutations, and Epigenetic's w/ Dr. Methylation & Glutathione: Unlock Your

Aging (Reduced Synthesis Capacity) As you age, production of glutathione declines due to: Reduced activity of gamma-glutamylcysteine ligase (GCL) , the rate-limiting enzyme in glutathione synthesis Decreased cellular energy (ATP) to fuel glutathione recycling Lower levels of precursor amino acids (especially cysteine and glycine) Studies show glutathione levels drop 10-15% per decade after age 40 [3]

doi: 10.1111/pce.12003 10 Clemente-MorenoM

The downstream effect is synergistic serotonergic amplification beyond the therapeutic window observed with either agent alone

While glyoxalase II substrate S-D-lactoylglutathione (SLG) acts as a precursor of the D-lactyl moiety for non-enzymatic D-lactylation, highlighting the multifaceted characteristics of lactylation as a biological regulatory system consisting of substrate specificity, lactate source, and enzyme dependence